No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese
- 1 August 1999
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 53 (3) , 642
- https://doi.org/10.1212/wnl.53.3.642
Abstract
Article abstract The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.Keywords
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