Effect of Haemodialysis on Erythrocyte and Plasma Potassium, Magnesium, Sodium and Calcium

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Abstract
Erythrocyte and plasma potassium, magnesium, sodium and calcium were estimated before and after dialysis in 32 studies on 14 patients undergoing recurrent haemodialysis. Predialysis erythrocyte magnesium was raised while sodium and calcium were depressed. Erythrocyte potassium varied depending on the total body potassium status of the patient. During dialysis erythrocyte potassium and magnesium fell but sodium and calcium increased. Changes in erythrocyte water or blood pH did not account for the shift of erythrocyte cations during dialysis. With recurrent dialysis changes in erythrocyte cations reflected the cumulative effect of individual dialysis and were towards a normal erythrocyte electrolyte composition. Erythrocyte magnesium resisted depletion despite low serum levels. Low dialysate magnesium levels (0.3–0.5 mg/100 ml) are required to maintain near normal serum and cellular magnesium concentrations.

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