The effect of exposure duration on the blood level of glucose pyruvate and lactate in acute carbon monoxide intoxication in man

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Abstract
Blood glucose, pyruvate and lactate were examined during hospitalization of 13 cases of acute carbon monoxide poisoning developing from short (≦ 1.5 h) or long (10–14 h) exposure. CO intoxication resulted in increased blood levels of all carbohydrate metabolites studied. Increased levels of pyruvate and lactate were much more pronounced and lasted for a longer time following long, compared with short, CO exposure despite similar blood COHb level (about 40% at the beginning of hospitalization).The results showed difference in biochemical effect of short and long single exposure to CO that could not be detected by the measurement of COHb.