Inhibition of Purine Nucleoside Phosphorylase by Phosphonoalkylpurines 1
- 1 January 1989
- journal article
- abstracts
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 8 (5) , 1039-1040
- https://doi.org/10.1080/07328318908054271
Abstract
Optimum inhibition of human erythrocyte purine nucleoside phosphorylase by 9-(phosphonoalkyl)hypoxanthines required an alkyl chain of five carbons or longer. Appropriate modifications of either the base or phosphonate side chain resulted in increased inhibitory activity.Keywords
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