Repeated exposure to Opisthorchis viverrini and treatment with the antihelminthic Praziquantel lacks carcinogenic potential
- 1 February 1992
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 13 (2) , 309-311
- https://doi.org/10.1093/carcin/13.2.309
Abstract
The effects of repeated Praziquantel administration, subsequent to infection and reinfection w Opisthorchis viverrini (OV), on lesion development in the Syrian hamster liver were investigated. Five applications of the antihelminthic drag were made (300 mg/kg body wt, i.g.), each time ∼5 weeks after dosing with 60–80 OV metacercarine at weeks 0, 8, 16, 24 and 32. The animals were then maintained until week 40 when they were killed; histopathological investigation revealed no significant development of either hepatocellular of cholangiocellular preneoplastic/neoplastic lesions. The results indicate that repeated exposure to Praziquantel at levels sufficient for successful removal of parasite infestation does not itself carry carcinogenic risk.Keywords
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