Enhancement of Ia-like antigen expression by interferon-gamma in polymorphonuclear leukocytes.
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 35 (1) , 436-439
- https://doi.org/10.1248/cpb.35.436
Abstract
The effects of interferons (IFNs) on Ia-like antigen expression in human peripheral blood polymorphonuclear leukocytes (PMNs) were examined in vitro using flow cytometry and FITC-labelled monoclonal antibody specific for the Ia-like antigen OKIa1. Recombinant human IFN-gamma markedly enhanced the expression of Ia-like antigen on PMNs and increased the number of Ia-positive PMNs. In contrast, natural human IFN-alpha and -beta had no effect on the expression when compared on the basis of antiviral activity.This publication has 8 references indexed in Scilit:
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