PENTOBARBITONE-BARBITONE ANAESTHESIA AND THYROID FUNCTION IN THE RAT

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Abstract
There are reports that di-ethyl ether and thiopentone depress thyroid function as measured by 131I uptake (Wase & Foster, 1956; Oyama, 1957), 131I incorporation into organic union and release by the gland (Oyama, 1959). However, pentobarbitone (Nembutal) in anaesthetic amounts for short periods is reported to have no significant effect on 131I release (Perry, 1951; Oyama, 1959). The present investigation describes effects on thyroid hormone metabolism and thyroid function during 8 hr. of surgical anaesthesia in the rat produced by a mixture of pentobarbitone and barbitone. Sprague-Dawley rats (Holtzman Farms), weighing between 250 and 300 g., were housed individually and fed ad libitum. The animals were injected with 10–20 μc 131I (Abbott Laboratories) 48 hr. before the start of the experiment, and 2 mg. methimazole (Tapazole, Lilly) per rat were injected i.p. 24 hr. before and again on the morning of the day of the

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