Two pericentric inversions, inv(2)(p11q13) and inv(5)(p13q13), in a patient referred for psychiatric problems

Abstract
Two pericentric inversions were found in the karyotype of a male patient referred for psychiatric problems. Cytogenetic analysis, using conventional Giemsa staining and G- and C.sbd.banding techniques, revealed a pericentric inversion in chromosome 2, inv(2)(p11q13), and chromosome 5, inv(5)(p13q13). The proband''s father carried both inversions also while other members were found to be carriers of either the inverted 2 or the inverted 5. This is the 1st report of 2 pericentric inversions to be found in the human genome.