New procedures for the Juliá–Colonna asymmetric epoxidation: synthesis of (+)-clausenamide
- 1 January 1998
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 10,p. 1159-1160
- https://doi.org/10.1039/a801450g
Abstract
The oxidation of chalcone 1 to optically active epoxide 2 [a precursor of (+)-clausenamide (+)-3] may be effected using a 15-mer or 20-mer of L-leucine bound to a PEG based support; poly-L-leucines of this type may be used as immobilised catalysts in a fixed-bed reactor.Keywords
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