Synthesis of Pyrroles via EthylN-(3-Oxo-1-alkenyl)glycinates
- 1 January 1990
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1990 (05) , 389-391
- https://doi.org/10.1055/s-1990-26883
Abstract
The reaction of ethyl glycinate hydrochloride (1) with 1,3-dicarbonyl compounds 2a-g in presence of triethylamine leads to the formation of ethyl N-(3-oxo-1-alkenyl)glycinates 3a-g. These compounds are easily converted to the pyrroles 4a-g by base-catalyzed intramolecular Knoevenagel condensation.Keywords
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