FORMATION OF A DNA-SOLUBLE RNA HYBRID AND ITS RELATION TO THE ORIGIN, EVOLUTION, AND DEGENERACY OF SOLUBLE RNA
Open Access
- 1 December 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (12) , 2101-2109
- https://doi.org/10.1073/pnas.48.12.2101
Abstract
It is possible to form ribonuclease-resistant hybrid complexes between sRNA and DNA. This suggests the existence of a sequence of nucleotides in the DNA complementary to the sRNA. When this complex is formed with an excess of sRNA, the DNA in one E. coli genome is saturated with approximately 40 sRNA molecules. If there is one site per sRNA molecule, this suggests that there is considerable degeneracy in the amino acid code. Hybrids have been formed between E. coli sRNA and DNA from a variety of bacterial species. Closer relatives form larger amounts of ribonuclease-resistant hybrid than distant relatives.Keywords
This publication has 19 references indexed in Scilit:
- Determination of the base composition of deoxyribonucleic acid from its buoyant density in CsClJournal of Molecular Biology, 1962
- THE SECONDARY STRUCTURE OF COMPLEMENTARY RNAProceedings of the National Academy of Sciences, 1962
- THE IDENTIFICATION OF THE RIBOSOMAL RNA CISTRON BY SEQUENCE COMPLEMENTARITY, I SPECIFICITY OF COMPLEX FORMATIONProceedings of the National Academy of Sciences, 1962
- Fractionation of nucleic acids with the methylated albumin columnJournal of Molecular Biology, 1962
- THE SELECTIVE SYNTHESIS OF INFORMATIONAL RNA IN BACTERIAProceedings of the National Academy of Sciences, 1961
- EXPERIMENTS ON HEMOGLOBIN BIOSYNTHESISProceedings of the National Academy of Sciences, 1961
- A HYBRID HELIX CONTAINING BOTH DEOXYRIBOSE AND RIBOSE POLYNUCLEOTIDES AND ITS RELATION TO THE TRANSFER OF INFORMATION BETWEEN THE NUCLEIC ACIDSProceedings of the National Academy of Sciences, 1960
- A fractionating column for analysis of nucleic acidsAnalytical Biochemistry, 1960
- Pseudouridine, a Carbon-Carbon Linked Ribonucleoside in Ribonucleic Acids: Isolation, Structure, and Chemical CharacteristicsJournal of Biological Chemistry, 1960
- INACTIVATION OF BACTERIOPHAGES BY DECAY OF INCORPORATED RADIOACTIVE PHOSPHORUSThe Journal of general physiology, 1955