The Differential sheep Cell Agglutination Test in Arthritis

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Abstract
The differential sheep cell agglutination test was performed on the serum of 26 patients with rheumatoid arthritis. In 13 patients a differential titer of 16 or over (positive reaction) was obtained. These patients were all considered to have clinically active disease and 10 of them had the disease for 3 or more years. The test was positive with scleroderma and in one with degenerative arthritic disease (osteoarthritis). In 108 patients with other forms of rheumatoid disorders or with diseases exhibiting rheumatic manifestations, the test was negative. Serum from 73 patients with a variety of non-rheumatic diseases and from 17 apparently healthy persons gave negative results. While these results are generally in accord with the observations of Rose and Sulkin, further investigation is needed to determine the practical diagnostic value of the test.