CYCLOSPORIN A AS SOLE IMMUNOSUPPRESSIVE AGENT IN RECIPIENTS OF KIDNEY ALLOGRAFTS FROM CADAVER DONORS - PRELIMINARY-RESULTS OF A EUROPEAN MULTICENTER TRIAL

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 2  (8289) , 57-60
Abstract
Human recipients (232) of cadaveric renal allografts were randomly allocated to receive either cyclosporin A (CyA, 117 patients) or azathioprine and steroids (control, 115 patients) for immunosuppression. After a follow-up period of up to 11 mo., graft survival probability estimates are 73% in the CyA group and 53% in the control group. Two deaths have occurred in the CyA group and 7 in the control group. Of the CyA group with functioning grafts 82% are receiving CyA alone, 17% have been changed to azathioprine and steroids, and 1 patient is receiving prednisolone in addition to CyA; 27% have never received steroids. At 6 mo. post-transplant, renal function is similar in patients receiving CyA and in those receiving azathioprine and steroids. CyA is apparently more effective than conventional immunosuppression. CyA therapy avoids the necessity of long-term steroid therapy.

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