Splenectomy in Hematologic Disorders

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Abstract
DURING the past sixty years splenectomy (Sx) has become a common procedure for the treatment of hypersplenism. Hypersplenism is a hematologic term describing premature destruction of blood cells by the spleen, usually with consequent anemia or leukocytopenia or thrombocytopenia — or all three. Dameshek established four signs of hypersplenism, the tetralogy consisting of cytopenia of the blood, corresponding hyperplasia of the precursor tissue in the bone marrow (e.g., thrombocytopenia with increased megakaryocytes), splenomegaly and — the clincher — cure of the cytopenia after Sx. There are exceptions to the first three rules. For example, in hereditary spherocytosis (HS) the red-cell . . .

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