Prevention of Restraint and Indomethacin-Induced Gastric Ulceration by Bile Duct or Pylorus Ligation in Rats

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Abstract
The influence of bile duct and pylorus ligation has been investigated on two experimental models of gastric ulceration. Both restraint and indomethacin induced gastric mucosal ulcerations were prevented by bile duct or pylorus ligation. This prevention was abolished by bile administration. It is concluded that the presence of bile in the stomach may be necessary for restraint or indomethacin induced ulceration. A short review of the literature on the effects of bile on gastricmucosa is alsopresented.