Hyaline Degeneration of Splenic Follicular Arteries in Infectious Mononucleosis: Histochemical and Electron Microscopic Studies

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Abstract
Histologic examination of the spleens of patients with infectious mononucleosis showed vasculitis and hyaline material in the center of follicles. The nature of the hyaline material was studied histochemically and electron microscopically. Our studies show that the hyaline or “amyloid-like” material in the follicles is comprised of two components: the larger hyalinized and fragmented material, presumably of damaged follicular artery in the central portion, surrounded peripherally by exuded plasma proteins, mainly fibrin. The degeneration of follicular arteries, vasculitis of larger vessels, and inflammation of the capsule evidently make the spleen susceptible to rupture. The mechanism of damage to the arteries in the follicles is unclear; however, interaction of many factors might be involved.

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