TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort
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Open Access
- 22 January 2007
- journal article
- research article
- Published by Springer Nature in Oncogene
- Vol. 26 (31) , 4596-4599
- https://doi.org/10.1038/sj.onc.1210237
Abstract
The identification of the TMPRSS2:ERG fusion in prostate cancer suggests that distinct molecular subtypes may define risk for disease progression. In surgical series, TMPRSS2:ERG fusion was identified in 50% of the tumors. Here, we report on a population-based cohort of men with localized prostate cancers followed by expectant (watchful waiting) therapy with 15% (17/111) TMPRSS2:ERG fusion. We identified a statistically significant association between TMPRSS2:ERG fusion and prostate cancer specific death (cumulative incidence ratio=2.7, PTMPRSS2:ERG fusion (PTMPRSS2:ERG fusion prostate cancers may have a more aggressive phenotype, possibly mediated through increased ERG expression.Keywords
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