TOXICITY OF VARIOUS CARRAGEENANS IN MOUSE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 57  (4) , 455-459
Abstract
Carrageenan toxicity varied according to the biochemical nature and source of material injected. Ischemic lesions of body extremities (acronecrosis) were produced by some but not all preparations. Histological examination of these sites and of both recent and old organ lesions (especially of liver and kidney) confirmed that the underlying pathology was disseminated intravascular coagulation. Evidence was also obtained that carrageenans are hepatotoxic.