RESISTANCE TO FIBROMA VIRUS INFECTION. THE ROLE OF IMMUNE LEUKOCYTES AND IMMUNE MACROPHAGES

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Abstract
Leukocytes and macrophages, obtained from fibroma-immune rabbits and added to immune serum-fibroma virus mixtures, significantly increased the neutralization of fibroma virus as compared with immune serum alone. Immune cell suspensions from peritoneal exudates, regional lymph nodes, buffy coats, spleen, and liver were all effective in inhibiting fibroma virus. Fibroma virus was not consistently and significantly inhibited by normal cells or cells from rabbits immunized with other viruses. Studies of the mechanism of action of the immune cells suggested that the effect was related to intracellularly placed antibody or to cellular transfer of an ability to form specific antibody in recipient animals.