Effect of diterpene esters on actin cytoskeleton of SV40-transformed keratinocytes is not reproduced by diacylglycerols
- 1 February 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 9 (2) , 333-334
- https://doi.org/10.1093/carcin/9.2.333
Abstract
The tumor promoter 12- O -tetradecanoylpborbol-13-acetate (TPA) induces a disorganization of the actin cytoskeleton and its redistribution at the periphery of the cells in SV40-transformed human keratinocytes. This phenomenon is induced by other diterpene esters, such as 4- O -methyl TPA, 12- O -ethacrynylphorbol-13-acetate (EPA), 12- O -retinoylphorbol-13-acetate (RPA) and mezerein, which exert either convertogenic or promoting effects in skin tumor development in vivo . Two diacylglycerols: oleyl-acetyl glycerol (OAG) and dioctanoylglycerol (DOG) do not induce the disorganization of actin. Thus, the effects of these compounds, as they are found in SV40-transformed human keratinocytes, do not exhibit clearcut correlations to either their protein kinase C activating abilities, or their effects on different stages of multistage carcinogenesis in mouse skin in vivo .Keywords
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