Recent Advances in the Mitsunobu Reaction: Modified Reagents and the Quest for Chromatography‐Free Separation
- 15 June 2004
- journal article
- review article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 2004 (13) , 2763-2772
- https://doi.org/10.1002/ejoc.200400003
Abstract
Recent progress in synthetic approaches to the Mitsunobu reaction are reviewed. Efforts that have focused on the phase‐switching modifications of phosphane, azodicarboxylate, and nucleophilic components are emphasized. An approach to product separation with fluorous compounds is reviewed in detail. Alternative reagents and recently introduced products are cited. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)Keywords
This publication has 121 references indexed in Scilit:
- Tablets of Functionalized Polystyrene Beads Alone and in Combination with Solid Reagents or Catalysts. Preparation and Applications in Parallel Solution and Solid Phase SynthesisJournal of Combinatorial Chemistry, 2003
- The Role of Acyloxyphosphonium Ions and the Stereochemical Influence of Base in the Phosphorane‐Mediated Esterification of AlcoholsAngewandte Chemie International Edition in English, 2003
- The Choice of Phosphane Reagent in Fukuyama−Mitsunobu Alkylation: Intramolecular Selectivity Between Primary and Secondary Alcohols in the Preparation of Asymmetric Tetraamine Building Blocks for Synthesis of PhilanthotoxinsEuropean Journal of Organic Chemistry, 2003
- Synthesis of Poly(aryl benzyl ether) Dendrimers on Solid SupportMacromolecules, 2003
- Synthesis and X-ray information of substituted gem-difluoroallenyl aminesJournal of Fluorine Chemistry, 2002
- An Approach to the Stereoselective Synthesis of syn- and anti-1,3-Diol Derivatives. Retention of Configuration in the Mitsunobu ReactionThe Journal of Organic Chemistry, 2002
- Practice of fluorous biphase chemistry: convenient synthesis of novel fluorophilic ethers via a Mitsunobu reactionJournal of Fluorine Chemistry, 2002
- The Mitsunobu reaction in the synthesis of α,α-difluoro-β-amino acidsJournal of Fluorine Chemistry, 2001
- Synthetic studies on the glycosylation of the base residues of inosine and uridineJournal of the Chemical Society, Perkin Transactions 1, 1999
- Esterification using a polymer-supported phosphine reagentThe Journal of Organic Chemistry, 1983