Chlorpromazine and Lidocaine Inhibit Antibody-Dependent Cell-Mediated Cytotoxicity but Not Erythrocyte Antibody Rosette Formation

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Abstract
Pretreatment of human peripheral blood mononuclear cells with chlorpromazine and lidocaine reduces their ability to induce lysis of antibody-coated target cells. This effect of local anesthetics was not due to a reduction of binding of antibody-coated red cells to the mononuclear cells, but it was rather probably due to the inhibition of mobility of the Fc receptor on the cell membrane.