Immunosuppressive Diterpenoids from Tripterygium wilfordii

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Abstract
A clinically used extract of Tripterygium wilfordii afforded three new diterpenoids3β,19-dihydroxyabieta-8,11,13-triene (triptobenzene L) (1); 12,19-dihydroxy-3-oxoabieta-8,11,13-triene (triptobenzene M) (2); and 19-hydroxy-3,7-dioxo-abieta-8,11,13-triene (triptobenzene N) (3)along with 14 known diterpenoids. The structures of 1−3 were established on the basis of spectroscopic studies. Of the known compounds, the stereochemistry at C-4 of triptonediol (4) was reassigned. Tripterifordin (8) and 13-epi-manoyl oxide-18-oic acid (9) showed significant inhibitory effects on cytokine production.