Synthesis of 1,2‐disubstituted isoindoles from o‐phthalaldehyde and primary amines
- 1 March 1985
- journal article
- research article
- Published by Wiley in Journal of Heterocyclic Chemistry
- Vol. 22 (2) , 449-451
- https://doi.org/10.1002/jhet.5570220248
Abstract
2‐Alkyl‐1(2‐formylphenyl‐N‐alkyliminomethyl)isoindoles were prepared by the reaction of o‐phthaldehyde with primary amines in 99% ethanol at 0°. 2‐Alkyl‐3‐alkyliminoisoindolinones were isolated from the reaction mixture as by‐products. Their formation mechanism is proposed.Keywords
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