Heterogenous response of B cell chronic lymphocytic leukaemia (B‐CLL) cells to anti‐human IgM antibody (anti‐μ) and B cell stimulatory factor 1 (BSF‐1)

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Abstract
Summary: B cell chronic lymphocytic leukaemia (B‐CLL) cells from seven patients were examined for 3H‐TdR uptake with anti‐human IgM antibody (anti‐μ) and B cell stimulatory factor 1 (BSF‐1)/IL‐4. B‐CLL cells from one patient could proliferate with anti‐μ plus BSF‐1, but not with BSF‐1 alone. B‐CLL cells from two patients responded to BSF‐1 alone; one could proliferate more by adding anti‐μ, but the proliferation of the other cells was inhibited by adding anti‐μ. On the other hand, B‐CLL cells from the other four patients responded neither to anti‐μ nor to anti‐μ plus BSF‐1. Surface densities of membrane IgM of B‐CLL cells were also analysed by fluorescence activated cell sorter (FACS), but there was no correlation between proliferative response (DNA synthesis) of B‐CLL cells to anti‐μ and densities of surface membrane IgM. These results show that there is a functional heterogeneity of B‐CLL cells with regard to proliferative response to anti‐μ and BSF‐1.

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