Spontaneous regression of intracutaneous cornifying epitheliomata in a dog

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Abstract
The clinical and histopathological features are described of a case of multicentric intracutaneous cornifying epitheliomata in a four‐year‐old German shepherd dog. Multiple lesions developed over a one‐and‐a‐half year observation period. Eighteen were surgically removed, many of the others spontaneously regressed. Novel histopathological features included prominent epithelial invasion of surrounding dermis and a high mitotic rate suggestive of squamous cell carcinoma, and the apparent origin of several tumours in hair shaft epithelium.