Utlization of d-3-hydroxy[3-14C]butyrate for lipogenesis in vivo in lactating rat mammary gland

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Abstract
Incorporation of D-3-hydroxy[3-14C]butyrate into lipid in vivo suggests that lactating mammary gland is a major site of ketone-body utilization. The incorporation decreases in short-term insulin deficiency (2 h) and on starvation (24 h), but increases again on refeeding (2 h). The activity of cytosolic acetoacetyl-CoA synthetase parallels the changes in nutritional state but is not affected by short-term insulin deficiency.