Blood Chemical Changes Following Intravenous Administration of a Casein Hydrolysate to Human Subjects.

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Abstract
Forty-five g. of Parenamine, a parenteral casein hydrolysate, dissolved in 1000 ml. of distilled water were injected into 30 hospital control subjects at a rate of 300 to 350 ml./hr. This resulted in an avg. plasma amino acid N rise of 4.9 mg./100 ml. during the injn. with a return to normal in 2 hrs. Rises to levels above 10 mg./lOO ml. produced by rapid injn. may be associated with nausea and vomiting. A progressive but slight rise in blood urea takes place during and after the injn., accompanied by increased urea excretion. Serum inorganic phosphate is lowered during the injn. and returns to normal by the end of the injn. Only a negligible drop in CO2 combining power occurred during the injn. Intraven. injected glucose did not alter the curves produced by the amino acid injn.

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