Short-Term Response of Testosterone, Dihydrotestosterone, 5α- And rostane-3β, 17β-diol, Testosterone-Glucosiduronate and Estradiol-17β as Measured in the Spermatic Vein of Human Male Subjects after Infusion of Gonadotropins

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Abstract
In 8 male subjects with normal testicular function, blood was drawn from the left spermatic vein and from the right cubital vein before and during an infusion of 4000 IU human chorionic gonadotropin (hCG) (preceded by a bolus of 1000 IU) or of 500 IU hCG plus human menopausal gonadotropin, respectively, within 30 min. Testosterone levels in the spermatic vein blood increased rapidly up to 518 or 215%, respectively. An increase of estradiol-17.beta. and of 5.alpha.-dihydrotestosterone concentrations in spermatic vein blood was observed only in 1 and 2 subjects, respectively. The human testicle releases also 5.alpha.-androstane-3.alpha.,17.beta.-diol and testosterone-glucosiduronate. Neither steroid responded to the short-term infusion of gonadotropins. The same holds true for all 5 steroids measured in peripheral vein blood.
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