Cushing's Syndrome Due to Islet Cell Carcinoma of the Pancreas

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Abstract
Two cases of Cushing''s syndrome due to islet cell carcinoma of the pancreas are presented. Twelve previously reported casea are reviewed. The characteristics of this disease are discussed; the absence of many of the usual manifestations of Cushing''s syndrome due to primary adrenocortical hyperplasia are pointed out. Aspergillosis complicated the first case and has not been previously identified in such patients. Increased excretion of 5-hydroxyindole acetic acid in the absence of a demonstrable carcinoid tumor was also found in the first case. The possibility that the pancreatic tumor produced two hormones is discussed. The second patient is the youngest reported to date. Elevated adrenocorticotropin-like activity was demonstrated in the tumor from this patient.

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