Effect of house dust mite on serum complement activation and total haemolytic activity in vitro in normal subjects and in patients with bronchial asthma

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Abstract
House dust mite (Dermatophagoides farinae) activated the complement system in vitro by both the classical and alternative pathways in normal serum and in 2 groups of (skin test positive and skin test negative) patients with bronchial asthma. The activation was dose dependent in the lower range of allergen concentrations. Skin test positive asthmatic subjects showed the maximum activation. Skin test negative patients had activation between skin test positive patients and normal subjects. At the higher allergen concentration normal serum and bronchial asthma patients showed similar results.