Failure of Bethanechol Denervation Supersensitivity as a Diagnostic Aid

Abstract
A total of 33 patients who demonstrated detrusor areflexia during cystometry underwent the bethanechol denervation supersensitivity test. In each instance the presence or absence of a neurologic lesion was documented carefully by complete neurologic evaluation. Of the 21 patients with a neurogenic bladder there was a false negative rate of 24%. Of the 12 patients without a neurogenic bladder the false positive rate was 50%. A positive bethanechol test is not by itself indicative of neurogenic bladder nor does a negative test exclude this diagnosis.