Differential regulation of IEGs in the rat PVH in single, and repeated stress models

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Abstract
Various kinds of stressors induce immediate early genes (IEGs) in discrete brain regions. We recently reported the reduced response of Fos expression in the hypothalamic paraventricular nucleus (PVH) when rats are repeatedly exposed to immobilization (IMO) stress. In this study, using in situ hybridization histochemistry, we further extended the research to other IEGs, and the results showed that prior exposure to IMO for 6 days suppressed the induction of fosB, junB and NGFI-B, but NGFI-A, mRNAs in response to a challenge IMO on day 7, suggesting that repeated stress has different effects on the transcription of NGFI-A and the other IEGs, in the PVH.

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