Age‐Dependent Differences in the Anticonvulsant Effects of 2–Amino‐7‐Phosphono‐Heptanoic Acid or Ketamine Infusions Into the Substantia Nigra of Rats
- 1 May 1992
- Vol. 33 (3) , 439-443
- https://doi.org/10.1111/j.1528-1157.1992.tb01688.x
Abstract
Summary: Infusions of 2‐amino‐7‐phosphonoheptanoic acid (AP7) or ketamine into the substantia nigra pars reticulata (SNPR) of adult rats increase the latency of onset to seizures induced by the convulsant ether flurothyl. Nigral infusions of AP7 or ketamine in concentrations up to 10 times greater than the adult dose are ineffective in 16‐day‐old rats. These results suggest that differences in seizure susceptibility between adult and immature rats may be related to differences in excitatory amino acid neurotransmission in the SN.Keywords
This publication has 26 references indexed in Scilit:
- Evidence for the involvement of nigral GABAB receptors in seizures of rat pupsDevelopmental Brain Research, 1989
- Intranigral GABAergic drug effects on striatal dopamine activityPharmacology Biochemistry and Behavior, 1989
- Age-related changes of muscimol binding in the substantia nigraDevelopmental Brain Research, 1988
- Nigral infusions of muscimol or bicuculline facilitate seizures in developing ratsDevelopmental Brain Research, 1987
- Only certain antiepileptic drugs prevent seizures induced by pilocarpineBrain Research Reviews, 1987
- Age-related changes in striatal dopamine activity following nigral muscimol infusionsDevelopmental Brain Research, 1987
- Comparative Stereostructure‐Activity Studies on GABAA and GABAB Receptor Sites and GABA Uptake Using Rat Brain Membrane PreparationsJournal of Neurochemistry, 1986
- Influence of excitatory amino acid receptor antagonists and of baclofen on synaptic transmission in the optic nerve to the suprachiasmatic nucleus in slices of rat hypothalamusNeuropharmacology, 1986
- Increased seizure susceptibility of the immature brainDevelopmental Brain Research, 1983
- Anticonvulsant Action of Excitatory Amino Acid AntagonistsScience, 1982