Aβ Oligomer-Induced Synapse Degeneration in Alzheimer’s Disease
- 3 May 2011
- journal article
- review article
- Published by Springer Nature in Cellular and Molecular Neurobiology
- Vol. 31 (6) , 939-948
- https://doi.org/10.1007/s10571-011-9691-4
Abstract
Aβ oligomers cause a collection of molecular events associated with memory loss in Alzheimer’s disease, centering on disrupting the maintenance of synapse structure and function. In this brief review of the synaptotoxic effects of Aβ oligomers, we focus on the neuronal properties governing oligomer targeting and toxicity—especially with respect to binding sites and mechanisms of binding. We also discuss ways in which mechanistic insights from other diseases offer clues in the pursuit of the molecular basis of Alzheimer’s disease.Keywords
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