METHYL 5(6)-4-2-PYRIDYL PIPERAZINO CARBAMOYL BENZIMIDAZOLE-2-CARBAMATE - A NEW BROAD-SPECTRUM ANTHELMINTIC

  • 1 January 1984
    • journal article
    • research article
    • Vol. 41  (3) , 279-286
Abstract
Methyl 5(6)-4-2-pyridyl piperazino carbamoyl benzimidazole-2-carbamate (CDRI Comp. 81-470) was tested against various nematode and cestode infections in different experimental and domestic animals. The compound showed 100% effectivity against adult of Ancylostoma ceylanicum (hookworm) in hamsters (6.25 mg/kg p.o. [orally] .times. 1), Nippostrongylus brasiliensis (trichostrongylid) in rats (100 mg/kg p.o. .times. 3), Hymenolepis nana (cestode) in rats (25 mg/kg p.o. .times. 1) and Syphacia obvelata (oxyurid) in mice (12.5 mg/kg p.o. .times. 3). It was also highly effective against artificial and natural helminth parasites of higher animals. The compound removed all, A. caninum and A. ceylanicum (hookworms) and Toxocara sp. (ascarid) from dogs at a dose of 10 mg/kg p.o. .times. 3; A. tubaeforme (hookworm) and Toxocara sp. at 25 mg/kg p.o. .times. 3 and 2.5 mg/kg p.o. .times. 3 respectively from cats and Ascaridia galli (ascarid) at 10 mg/kg p.o. .times. 3 from fowl. The compound in doses of 1500 mg/kg by oral route and 1000 mg/kg by i.p. [intraperitoneal] route did not cause any mortality or produce adverse effect in mice. The expanded anthelmintic action and large therapeutic index indicate compound''s great anthelmintic potentiality.

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