Towards the Total Synthesis of Manzamines: Preparation and Reactions of 2-Methoxycarbonyl-1,3-butadienes and β-Amino Aldehydes1,2
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (04) , 275-278
- https://doi.org/10.1055/s-1992-21337
Abstract
The rapid and versatile syntheses of N,N-disubstituted 1-aminoethyl-2-methoxycarbonyl-1,3-butadienes 12 via ß-amino aldehydes 13, and 2-methoxycarbonyl-1-propyl-1,3-butadiene (7) are reported. The reactivity , of these dienes in the Diels-Alder reaction to form nitrogen heterocycles 8-10, 15 and 16, and their potential use in the synthesis of manzamines is discussed.Keywords
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