Elevated IL-6 and TNF-α levels in patients with ALS: Inflammation or hypoxia?
- 27 December 2005
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 65 (12) , 1958-1960
- https://doi.org/10.1212/01.wnl.0000188907.97339.76
Abstract
Abnormal levels of interleukin (IL)-6 were described in patients with ALS, related to an inflammatory process. The authors compared IL-6 and tumor necrosis factor α (TNF-α) levels in CSF and sera from 10 hypoxemics and 10 normoxemics patients with ALS to those of 10 hypoxemics and 10 normoxemics neurologic controls. The same pattern exists in patients with ALS and controls: the highest levels are found in hypoxic conditions and undetectable levels are found in normoxemic conditions. Elevated IL-6 levels in ALS could correspond to a normal response to hypoxemia.Keywords
This publication has 5 references indexed in Scilit:
- PGE2 receptors rescue motor neurons in a model of amyotrophic lateral sclerosisAnnals of Neurology, 2004
- Increased cytotoxic potential of microglia from ALS‐transgenic miceGlia, 2004
- Plasma cytokine levels in patients with obstructive sleep apnea syndrome: a preliminary studyJournal of Sleep Research, 2003
- Respiratory muscle strength and ventilatory failure in amyotrophic lateral sclerosisBrain, 2001
- Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degenerationNature Genetics, 2001