Effect of a Low-Protein Diet on Urinary Albumin Excretion in Uremic Patients

Abstract
Fifteen patients with advanced renal failure (creatinine clearance < 25 ml/mm) and with severe albumin-uria (< 1.5 g/24 h) were put on a low-protein (0.3 g/kg body weight), low-phosphorus (5-7 mg/kg body weight) diet supplemented with essential amino acids and ketoanalogues. During the 6-month follow-up, urinary albumin excretion and fractional renal albumin clearance were reduced significantly while serum albumin concentration increased; no nutritional change occurred during the study.