Malignant lymphomas with band 8q24 chromosome abnormality: a morphologic continuum extending from Burkitt's to immunoblastic lymphoma

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Abstract
Chromosome abnormality involving band 8q24 is present in the malignant cells in virtually all Burkitt''s type malignancies. t(8;14)(q24;q32) translocations have nevertheless been found in certain cases of malignant lymphomas (ML) described as small non-cleaved non-Burkitt, immunoblastic or histiocytic. With a view to comparing objectively the histological picture of such lymphomas, morphometric analysis was undertaken of 7 cases of diffuse ML classed as Burkitt''s (3 cases), immunoblastic (2 cases), small non-cleaved non-Burkitt (1 case) and large-cell lymphoma (1 case), all exhibiting band 8q24 rearrangement arising from various translocations. The histologic picture of ML with 8q24 anomaly apparently fits into a morphological continuum containing Burkitt''s, small non-cleaved non-Burkitt and immunoblastic lymphomas.