Identification of the N-acetylcysteine conjugate of benzidine formed in the peroxidase activation system
- 1 January 1985
- journal article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 6 (1) , 155-158
- https://doi.org/10.1093/carcin/6.1.155
Abstract
Benzidine is oxidized by the peroxidase/H2O2 system, yielding reactive intermediates. In the presence of thiols, covalent adducts are formed. We used h.p.l.c. to separate the products of the reaction of benzidine with N-acetylcysteine. The major product was identified by n.m.r. spectroscopy (1H-n.m.r.) as 3-(N-acetylcystein-S-yl)-benzidine.Keywords
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