Application of the least-squares method in the matrix form: simultaneous spectrophotometric determination of rifampicin and isoniazid in binary pharmaceutical formulations
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 114 (10) , 1311-1314
- https://doi.org/10.1039/an9891401311
Abstract
A least-squares method in the matrix form is described for the simultaneous determination of rifampicin and isoniazid in a mixture. The method allows the rapid analysis of binary pharmaceutical formulations with minimum error. The concentration of each component in the mixture has been determined spectro-photometrically by measuring the absorbance of the mixture at 5-nm intervals from 230 to 290 nm. To calculate the matrix of the proportionality constant a standard mixture was used for each component. All data analyses were performed on a personal computer.Keywords
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