Enantioselective Copper-Catalyzed SN2′ Substitution with Grignard Reagents
- 31 December 2001
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2001 (Special ) , 0927-0930
- https://doi.org/10.1055/s-2001-14626
Abstract
Cinnamyl chlorides undergo selective SN2′ allylic substitution by Grignard reagents using catalytic amount (1 mol%) of CuCN and 1-2 mol% trivalent phosphorus ligands, in dichloromethane. With chiral phosphorus ligands derived from TADDOL ee's up to 73% could be obtained.Keywords
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