SPONTANEOUS LYMPHOCYTE-TRANSFORMATION IN CHRONIC LYMPHOCYTIC-LEUKEMIA

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 28  (3) , 542-545
Abstract
In 10 patients with CLL [chronic lymphatic leukemia] and in 8 controls T [thymus-derived] lymphocytes were separated out by the rosetting method. The in vitro reactivity of these cells and of unseparated lymphocytes was studied in cultures without stimulants. A new increase of spontaneous lymphocyte transformation was found in the populations enriched with T cells in patients with CLL with respect to analogous populations in the controls. This increase is interpreted as a cell-mediated immunological reaction and due to T-cell sensitization towards the neoplastic B [bone marrow-derived] cells.