Note. —It has been the custom of the Russell Sage Institute of Pathology to publish each year a group of seven or eight papers embodying the work of the previous season. This year practically the whole staff is on active duty in the army or the navy and it has been considered advisable to present three of the papers without waiting for the whole series. It is hoped at a later date to publish the work on temperature regulation after the intravenous injection of typhoid vaccine, on metabolism in tubercular fever, in erysipelas, in acute and chronic arthritis, and also a summary of the diets that have been used in the metabolism ward. It has been impossible this year to review the literature as fully as has been done in the other papers of this series. In order to compare the metabolism of different individuals, it has been customary to