Cefoxitin in the Treatment of Gonorrhea

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Abstract
Cefoxitin is active in vitro against .beta.-lactamase-producing strains of Neisseria gonorrhoeae; its efficacy in the treatment of uncomplicated genital gonorrhea was evaluated in a study of 10 men and 15 women. Cefoxitin was administered in 2 i.m. doses given 5 h apart, patients alternately receiving 1 or 2 g of cefoxitin in each injection. Probenecid (1 g) was administered orally with both injections to 5 women, and with the 1st injection only in the remaining patients. All cases of gonococcal cervicitis or urethritis were cured, and all rectal carriage was eliminated. Four of 7 patients had persistent oropharyngeal carriage after treatment. There was no discernible difference between the efficacies of the 1 and 2 g regimens. The cefoxitin regimens used are effective for therapy of uncomplicated genital or anorectal gonorrhea, but not for eradication of oropharyngeal carriage of N. gonorrhoeae.

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