Model of interaction of the IL‐1 receptor accessory protein IL‐1RAcP with the IL‐1β/IL‐1RI complex
- 14 June 2001
- journal article
- Published by Wiley in FEBS Letters
- Vol. 499 (1-2) , 65-68
- https://doi.org/10.1016/s0014-5793(01)02515-7
Abstract
A preliminary model has been calculated for the activating interaction of the interleukin 1 receptor (IL-1R) accessory protein IL-1RAcP with the ligand/receptor complex IL-1β/IL-1RI. First, IL-1RAcP was modeled on the crystal structure of IL-1RI bound to IL-1β. Then, the IL-1RAcP model was docked using specific programs to the crystal structure of the IL-1β/IL-1RI complex. Two types of models were predicted, with comparable probability. Experimental data obtained with the use of IL-1β peptides and antibodies, and with mutated IL-1β proteins, support the BACK model, in which IL-1RAcP establishes contacts with the back of IL-1RI wrapped around IL-1β.Keywords
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