Immunogenicity of Leptospiral Vaccines Grown in Protein-free Medium
- 1 November 1982
- journal article
- research article
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 15 (4) , 493-501
- https://doi.org/10.1099/00222615-15-4-493
Abstract
Leptospira interrogans serovars pomona and hardjo were adapted to grow in a chemically-defined, protein-free (PF) medium. Formolized monovalent vaccines of serovars pomona and hardjo and a bivalent mixture of the two were prepared from PF cultures. Live PF cultures and the vaccine preparations retained their agglutinating antigens and their immunogenicity when tested in rabbits and guinea-pigs. The vaccines were not pyrogenic; dermal reactions were slight.This publication has 1 reference indexed in Scilit:
- Chapter VIII Serological Typing Methods of LeptospiresPublished by Elsevier ,1978