The Absence of an Effect of Photoreactivation on Sub-lethal Damage Accumulation in a Photoreactive Wallaby Cell-line
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 34 (1) , 73-79
- https://doi.org/10.1080/09553007814550641
Abstract
Monolayer cultures of JU56 wallaby cells were exposed to germicidal U.V. and/or photoreactivating (PR) light. The U.V. exposures induced dose-dependent cell-death. The survival data are consistent with a common extrapolation number (n) of 6·17 ± 0·98 with a D0 of 123·0 ± 6·8 erg/mm2 for photo-reactivated cells and a D0 of 87·0 ± 4·9 erg/mm2 for non-photoreactivated cells; the photoreactivation protected the cells with a dose-modification factor of 1·41 ± 0·02. Therefore PR is not a shoulder phenomenon and so has no relationship to the repair of sub-lethal damage.This publication has 12 references indexed in Scilit:
- POST‐IRRADIATION EFFECTS OF PHOTOREACTIVATING LIGHT AND CAFFEINE ON CULTURED MARSUPIAL CELLS EXPOSED TO ULTRAVIOLET LIGHTPhotochemistry and Photobiology, 1973
- Human bone marrow colony growth in agar‐gelJournal of Cellular Physiology, 1970
- Phosphodiesterase in PsoriasisBritish Journal of Dermatology, 1970
- Photoreactivating-enzyme activity in metazoa.Proceedings of the National Academy of Sciences, 1967
- Photoreactivation: A radiation repair mechanism absent from mammalian cellsBiochemical and Biophysical Research Communications, 1966
- Effects of ultraviolet radiation on mammalian cells I. Induction of chromosome aberrationsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1965
- X-Ray and Ultraviolet Sensitivity of Synchronized Chinese Hamster Cells at Various Stages of the Cell CycleBiophysical Journal, 1965
- PHOTOREACTIVATIONMicrobiology and Molecular Biology Reviews, 1958
- PLAQUE FORMATION AND ISOLATION OF PURE LINES WITH POLIOMYELITIS VIRUSESThe Journal of Experimental Medicine, 1954