EOG IN A LARGE FAMILY WITH HEREDITARY MACULAR DEGENERATION

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Abstract
A total of 128 descendants from 1 large family with a history of hereditary macular degeneration (HMD) were examined with EOG [electrooculography]. Of these, 42 were affected patients, 48 were healthy offspring to affected parents and 38 were normal controls. Affected subjects had a light peak/dark trough [Lp/Dt] ratio smaller than 1.40. In the group of offspring of affected patents the Lp/Dt ratios showed a bimodal distribution dividing the group into 2 parts, one with values less than 1.40 and another with values larger than 1.70. Carriers of the HMD gene can apparently be identified by the use of EOG. The affected subjects and the carriers had a lower base value of the standing potential than the controls.